Op-brai120243 400..411
نویسندگان
چکیده
1 Division of Brain Sciences, Department of Medicine, Hammersmith Hospital, Imperial College London, London W12 0NN, UK 2 Reta Lila Weston Institute of Neurological Studies, Department of Molecular Neuroscience, University College London, London WC1N 1PJ, UK 3 Wellcome Department of Imaging Neuroscience, UCL Institute of Neurology, University College London WC1N 3BG, UK 4 Section of Neurology, Department of Neurosciences, University of Pisa, 56126 Pisa, Italy 5 School of Psychology, Cardiff University, Cardiff CF10 3AT, UK
منابع مشابه
Detection of adduct on tyrosine 411 of albumin in humans poisoned by dichlorvos.
Studies in mice and guinea pigs have shown that albumin is a new biomarker of organophosphorus toxicant (OP) and nerve agent exposure. Our goal was to determine whether OP-labeled albumin could be detected in the blood of humans exposed to OP. Blood from four OP-exposed patients was prepared for mass spectrometry analysis by digesting 0.010 ml of serum with pepsin and purifying the labeled albu...
متن کاملImmunodetection of serum albumin adducts as biomarkers for organophosphorus exposure.
A major challenge in organophosphate (OP) research has been the identification and utilization of reliable biomarkers for the rapid, sensitive, and efficient detection of OP exposure. Although Tyr 411 OP adducts to human serum albumin (HSA) have been suggested to be one of the most robust biomarkers in the detection of OP exposure, the analysis of HSA-OP adduct detection has been limited to tec...
متن کاملImmunodetection of Serum Albumin Adducts as Biomarkers for Organophosphorus Exposure s
A major challenge in organophosphate (OP) research has been the identification and utilization of reliable biomarkers for the rapid, sensitive, and efficient detection of OP exposure. Although Tyr 411 OP adducts to human serum albumin (HSA) have been suggested to be one of the most robust biomarkers in the detection of OP exposure, the analysis of HSA-OP adduct detection has been limited to tec...
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Tyrosine 411 of human albumin is an established site for covalent attachment of 10-fluoroethoxyphosphinyl- N-biotinamidopentyldecanamide (FP-biotin), diisopropylfluorophosphate, chlorpyrifos oxon, soman, sarin, and dichlorvos. This work investigated the hypothesis that other residues in albumin could be modified by organophosphorus agents (OP). Human plasma was aggressively treated with FP-biot...
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